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Two Sigma Ventures

Investor type Venture Capital


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This summary is composed by our algorithm based on the analysis of the deals. If you think that some of this information is not accurate, please let us know about it and provide any supporting evidences if possible. Such cases will be analyzed by our ML-algorithm and implemented in our database, which will improve this summary.
Total investments 187
Average round size
The average size of a deal this fund participated in
Portfolio companies 87
Rounds per year 18.70
Lead investments 22
Follow on index
How often the fund supports its portfolio startups at next rounds
Exits 15
Key employees 4
Stages of investment
Early Stage Venture

Areas of investment

  • Software
  • Machine Learning
  • SaaS
  • Artificial Intelligence
  • Biotechnology

Two Sigma Ventures is the famous VC, which was founded in 2012. The leading representative office of defined VC is situated in the New York. The company was established in North America in United States.

Besides them, we counted 4 critical employees of this fund in our database.

For fund there is a match between the country of its foundation and the country of its the most frequent investments - United States. The fund has no specific favorite in a number of founders of portfolio startups. When startup sums 5+ of the founder, the probability for it to get the investment is little. Among the most successful fund investment fields, there are Software, Health Care. Among the most popular portfolio startups of the fund, we may highlight Mesosphere, Zymergen, Anki. Besides, a startup requires to be at the age of 2-3 years to receive the investment from the fund.

The fund is constantly included in 7-12 investment rounds annually. The increased amount of exits for fund were in 2019. Comparing to the other companies, this Two Sigma Ventures performs on 26 percentage points less the average number of lead investments. The usual things for fund are deals in the range of 10 - 50 millions dollars. The high activity for fund was in 2018. The typical startup value when the investment from Two Sigma Ventures is 100-500 millions dollars. Considering the real fund results, this VC is 2 percentage points less often commits exit comparing to other organizations.

The standard case for the fund is to invest in rounds with 6-7 partakers. Despite the Two Sigma Ventures, startups are often financed by Highland Capital Partners, Founder Collective, Andreessen Horowitz. The meaningful sponsors for the fund in investment in the same round are Madrona Venture Group, Highland Capital Partners, Andreessen Horowitz. In the next rounds fund is usually obtained by Highland Capital Partners, Threshold, Madrona Venture Group.

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Funds investing in previous rounds
These funds often invest in the rounds preceeding the rounds of Two Sigma Ventures:
Typical Co-investors
Two Sigma Ventures is more likely to invest in rounds together with the following funds:
Funds investing in following rounds
These funds have a tendency to invest in the following rounds after Two Sigma Ventures:

Funds with similar focus

Funds from United States
Funds with similar focus located in United States:
Funds with the same geo focus
Funds with similar geography of portfolio companies:
Funds doing lead investments
Funds with similar focus acting as lead investors:

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Notable deals

CompanyIndustryRound SizeDateInvestorsLocation


Cloud Data Services
Management Information Systems
$50M27 Sep 2022 Denver, Colorado, United States


Health Care
Health Diagnostics
Life Science
$19M13 Jul 2022 Durham, North Carolina, United States

Isabl Inc.

Health Diagnostics
$3M18 May 2022 -


Enterprise Software
Internet of Things
Supply Chain Management
$54M11 Apr 2022 Boston, Massachusetts, United States


Financial Services
Human Resources
Service Industry
$300M05 Apr 2022 San Francisco, California, United States


Mobile Apps
$15M24 Feb 2022 San Francisco, California, United States


Information Services
$110M22 Feb 2022 New York, New York, United States


Health Care
$236M15 Feb 2022 New York, New York, United States

Rift Finance

$18M08 Feb 2022 New York, New York, United States
Hexagon Bio Raises $61 Million to Advance Novel Small-Molecule Medicines Mined from Microbial Genomes

– Hexagon Bio, a biopharmaceutical company pioneering the discovery of medicines encoded in the global metagenome, announced that it has raised $61 million to fuel the continued development of its platform to design and develop new therapeutics mined from microbial genomes.
Nextech Invest led the financing, with participation from new investors SoftBank Vision Fund 2* and Casdin Capital, as well as existing investors The Column Group, 8VC, and Two Sigma Ventures.
– Hexagon’s interdisciplinary platform combines technological advances and proprietary insights across machine learning, genomics, synthetic biology and automation to systematically discover new chemical compounds linked to known protein targets.
– Hexagon has built a database of microbial genomes that is more than twice the size of all public databases and is adding thousands of additional genomes per month.

Sora’s HR automation software raises $14M Series A

– HR automation software startup Sora announced that it closed a $14 million Series A round of funding.
Two Sigma Ventures led the financing event, putting in $10 million, with prior investors completing the round.
First Round and Elad Gil led that investment.


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